Measurement of antimicrobial agents in serum and body fluids biological assys immunoassays. Measurement of antimicrobial agents in serum and body fluids.
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Measurement of antimicrobial agents levels in body fluids. Laboratory tests that are usually considered helpful in guiding antimicrobial therapy include antimicrobial agent susceptibility tests determination of bacterial production of beta lactamase and assay of specific antimicrobial levels in serum and other body fluids. These studies suggest that the level of antimicrobial drug in sputum and bronchial secretions is of clinical impor tance. Microbioassay of antimicrobial agents haroldj. Levels correlated with a statistically significant improvement in clinical outcome and a lower mortality. In contrast dilution methods allow determination of the minimal inhibitory concentration of an agent which can be correlated with blood urine and other body fluid levels of the antimicrobial agent. Persistent suppression of bacterial growth after limited exposure to an antimicrobial agent 1.
Poor clinical response being correlated with levels lower than the mic of the specific pathogen 12 15. Concentration of antibacterial agents in interstitial tissue fluid. The values given for serum and urine were obtained from normal adults in controlled phar macologic studies table 1. Antimicrobial levels and renal function for most antimicrobial agents renal excretion is the major pathway for elimination from the. Jong yin department ofcommunity medicine schoolofmedicine university ofcalifornia sandiego lajolla california 92037 received for publication 10november 1969 apreviously described agar diffusion technique for microbioassay ofantimicro. Most distribute well into various body fluids do not distribute well into csf unless meninges are inflamed.
For the other body fluids listed the subjects were generally hospitalized patients table 2. With the availability of rapid accurate assays the measurement of antibiotic material in serum and other body fluids is feasible desirable and widely practiced for these purposes. Pmc free article georgopoulos a. Chisholm gd waterworth pm calnan js garrod lp. If the tracer is metabolised a series of measurements can be made and assuming exponential decline first order kinetics the volume of distribution can be determined by extrapolation back to zero time. The measurement of antibiotic concentrations in various fluids has been a prominent aspect of the evaluation of new antibiotics and the quality control of their manufacture.
Production greatly increased after. Accurate measurement of serum concentrations of antimicrobial agents is important when the margin between therapeutic and toxic levels is narrow. 4efficacy or toxicity is delayed or difficult to measure 5accurate assay is available. Constitutive inducible produced at low level wo stimulus. A simple micro agar diffusion method for the determination of antibiotic concentrations in blood and other body fluids. Not interfere with body fluid distribution if the tracer is excreted in the urine then the loss can be determined and corrections made in the calculation.
Gallery of Measurement Of Antimicrobial Agents Levels In Body Fluids
